Fri Nov 11 2022

34 articles - From Friday Nov 04 2022 to Friday Nov 11 2022

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Atypical Hemolytic Uremic Syndrome Occurring After Receipt of mRNA-1273 COVID-19 Vaccine Booster: A Case Report.

In addition, there is one reported case of aHUS occurring after receipt of the adenovirus-based COVID-19 vaccine ChAdOx1 nCoV-19, but, to our knowledge, this is the first case of aHUS occurring after a booster dose of an mRNA COVID-19 vaccine in a patient with an underlying pathogenic variant in complement C3. Given the time frame, we hypothesize that the vaccine probably was the trigger for development of aHUS in this patient.

Pubmed   Journal   ReadQx   PMC

Light Chain-Only Immunotactoid Glomerulopathy: A Case Report.

We describe a light chain-only variant of ITG. Pathogenesis potentially involves activation of the alternative pathway of complement by a nephrotoxic light chain.

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Clin J Am Soc Nephrol

Characterization of Glomerular and Tubulointerstitial Proteomes in a Case of NSAID-Attributed Acute Kidney Injury.

This diagnosis was supported by analysis of the glomerular and tubulointerstitial proteomes. The proteomic interrogation revealed a molecular landscape that demonstrated differences in kidney prostaglandin synthesis that may be in response to NSAIDs, as well as signs of intra-renal inflammation and fibrosis that were not evident by histopathology alone.

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Development and Validation of a Lifetime Risk Model for Kidney Failure and Treatment Benefit in Type 2 Diabetes: 10-Year and Lifetime Risk Prediction Models.

This study derived and externally validated a prediction tool for estimating 10-year and lifetime risks of kidney failure as well as life years free of kidney failure gained with preventive treatment in individuals with type 2 diabetes using easily available clinical predictors. Podcast This article contains a podcast at

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J Am Soc Nephrol

A Population-Based Analysis of the Risk of Glomerular Disease Relapse after COVID-19 Vaccination.

In a population-level cohort of patients with glomerular disease, a second or third dose of COVID-19 vaccine was associated with higher relative risk but low absolute increased risk of relapse.

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Can Kidney Organoid Xenografts Accelerate Therapeutic Development for Genetic Kidney Disorders?

This methodology holds great potential for drug discovery. Under Recent studies using kidney organoid xenografts highlighted the unique potential of this novel methodology for elucidating molecular mechanisms driving monogenic kidney disorders and for the development ofnovel pharmacotherapies.

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The Role of Platelet-Derived Growth Factor in Focal Segmental Glomerulosclerosis.

Although podocyte injury initiates FSGS, parietal epithelial cells (PECs) are the main effectors. Because PDGF takes part in fibrotic processes, we hypothesized that the ligand PDGF-B and its receptor PDGFR- molecular crosstalk between podocytes and PECs drives glomerulosclerosis and the progression of FSGS.

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Kidney Int

A Banff-based histologic chronicity index is associated with graft loss in patients with a kidney transplant and antibody-mediated rejection.

The association of the chronicity index of 4 or greater with graft loss was confirmed in an independent cohort of 61 patients from Necker Hospital, Paris. Thus, our findings suggest the chronicity index may be valuable as a simplified approach to decision-making in patients with AMR.

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A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury.

Thus, F4/80 hi macrophages express interleukin-1 receptor antagonist and constrain interleukin-6 generation from endothelial cells to limit septic AKI, representing a targetable cellular crosstalk in septic AKI. These findings are particularly relevant owing to the efficacy of anti-interleukin-6 therapies during COVID-19 infection, a disease associated with high rates of AKI and endothelial dysfunction.

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Anomalous kinetics of galactose-deficient IgA incurring nephropathy revealed by cross-scale optical imaging.

Thus, our study highlights that the aberrant kidney depositional kinetics of Gd-IgA is involved in the pathogenesis of IgAN. Hence, cross-scale optical imaging has potential applications in assessing immune-mediated kidney diseases and uncovering underlying mechanisms of disease.

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Association between cholinesterase inhibitors and kidney function decline in patients with Alzheimer's dementia.

Results were consistent across subgroups, ChEI subclasses and after accounting for competing risks. Thus, in patients with AD undergoing routine care, use of ChEI (vs no-use) was associated with lower risk of CKD progression.

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Effects of aspirin on cardiovascular outcomes in patients with chronic kidney disease.

With tertiles of eGFR under 70, 70-90, and over 90 ml/min/1.73 m 2 , risk reductions with aspirin for the primary outcome were larger at lower eGFR levels (0.62; 0.43-0.91) for the lowest tertile, (0.96; 0.62-1.49) for the middle, and (1.30; 0.77-2.18) for the highest tertile. Thus, our findings support aspirin may reduce cardiovascular events in people with moderate to advanced stage CKD.

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Kidney tubular transcription co-activator, Yes-associated protein 1 (YAP), controls the expression of collecting duct aquaporins and water homeostasis.

These three factors also promoted Aqp4 transcription whereas only GATA2 and GATA3 enhanced Aqp3 transcription. Thus, our results suggest that YAP promotes Aqp2 and Aqp4 transcription, interacts with GATA2, GATA3 and NFATc1 to control Aqp2 expression, while Aqp-2, -3 and -4 exploit overlapping mechanisms for their baseline transcriptional regulation.

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The oxidative phosphorylation inhibitor IM156 suppresses B-cell activation by regulating mitochondrial membrane potential and contributes to the mitigation of systemic lupus erythematosus.

Thus, our data indicated that IM156 suppressed the mitochondrial membrane potentials of activated B-cells in mice, contributing to the mitigation of lupus activity. Hence, IM156 may represent a therapeutic alternative for autoimmune disease mediated by B-cell hyperactivity.

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Unique problems for the design of the first trials of transplanting porcine kidneys into humans.

We set expectations related to the importance of informing and protecting family members and medical teams who could be exposed to zoonotic viral infection from the donor organ and/or receive unwanted publicity. Meeting these challenges in trial design and oversight will require multidisciplinary expertise, a conceptual model that extends beyond the individual patient, and creative collaboration between scientists and regulatory agencies.

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Nephrol Dial Transplant

Design and Population of the VALOR-CKD Study: A Multicenter, Randomized, Double-Blind Placebo-Controlled Trial Evaluating the Efficacy and Safety of Veverimer in Slowing Progression of Chronic Kidney Disease in Patients with Metabolic Acidosis.

VALOR-CKD has recruited a large population of people with metabolic acidosis at high risk for CKD progression to determine the effects of veverimer on the risk of progressive loss of kidney function.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Autoimmunity in Anti-Glomerular Basement Membrane Disease: A Review of Mechanisms and Prospects for Immunotherapy.

An understanding of these autoimmune responses may open opportunities to explore potential new therapeutic approaches for this disease. We review how current advances in epitope mapping, identification of novel autoantigens, and the phenomena of epitope spreading and mimicry have heightened the understanding of autoimmunity in the pathogenesis of anti-GBM disease, and we discuss prospects for immunotherapy.

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Intensive Care Unit-Acquired Weakness in Patients With Acute Kidney Injury: A Contemporary Review.

We next discuss the currently available interventions that may mitigate the risk of ICU-AW in patients with AKI and AKI-KRT. We conclude that additional studies are needed to better characterize the epidemiologic and pathophysiologic relationship between AKI, AKI-KRT, and ICU-AW and to prospectively test interventions to improve the long-term functional status and quality of life of AKI survivors.

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Lighthouses of Constancy.

Pubmed   Journal   ReadQx 

Pediatric Vaccine Hesitancy and COVID-19.

Pubmed   Journal   ReadQx   PMC

J Am Soc Nephrol

Artificial Intelligence You Can Trust: What Matters Beyond Performance When Applying Artificial Intelligence to Renal Histopathology?

Therefore, determining the optimal design for AI systems depends on factors beyond performance, with considerations of goals, interpretability, and safety constraining many design and engineering choices. In this article, we explore challenges that arise in the application of AI to renal histopathology, and consider areas where choices around model architecture, training strategy, and workflow design may be influenced by factors beyond the final performance metrics of the system.

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mRNA COVID-19 Vaccines and Their Risk to Induce a Relapse of Glomerular Diseases.

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Slit Diaphragms: Junctions That Never Sleep.

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Nat Rev Nephrol

Oxalate homeostasis.

Beyond well-known interventions (such as dietary modifications), novel therapeutics (such as small interfering RNA gene silencers, recombinant oxalate-degrading enzymes and oxalate-degrading bacterial strains) hold promise to improve the outlook of patients with oxalate-related diseases. In addition, experimental evidence suggests that anti-inflammatory medications might represent another approach to mitigating or resolving oxalate-induced conditions.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Kidney Dis

Effectiveness of Pharmacological Interventions for Treatment of Osteoporosis in Patients With CKD 3-5D: No Clear Choices.

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Effectiveness of Pharmacological Interventions Versus Placebo or No Treatment for Osteoporosis in Patients With CKD Stages 3-5D: Editorial Summary of a Cochrane Review.

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Clin J Am Soc Nephrol

How I Treat Steroid-Sensitive Nephrotic Syndrome in Children.

Pubmed   Journal   ReadQx 

Management of Patients with Kidney Failure and Pericarditis.

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Organizing Nephrologists at the State Level.

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Nephrol Dial Transplant

Humoral and cellular responses after a third dose of SARS-CoV-2 mRNA vaccine in patients with glomerular disease.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Kidney Dis

Estimated Versus Measured Glomerular Filtration Rate in Men at Risk for Mesoamerican Nephropathy.

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Pharmacokinetics and Pharmacodynamics of Apixaban in Nephrotic Syndrome: Findings From a Phase 1a Trial.

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Clin J Am Soc Nephrol

Effects of Dapagliflozin in People without Diabetes and with Microalbuminuria.

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Kidney Int

SARS-CoV-2 vaccination improves HBV seroconversion rate through heterological immunity.

Pubmed   Journal   ReadQx   PMC